Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenosine Phosphorylase (MTAP), an Exploitable Tumor Target Authors and Affiliations

نویسندگان

  • Colin C Collins
  • Stanislav V Volik
  • Anna V Lapuk
  • Yuwei Wang
  • Peter W Gout
  • Chunxiao Wu
  • Hui Xue
  • Hongwei Cheng
  • Anne Haegert
  • Robert H Bell
  • Sonal Brahmbhatt
  • Shawn Anderson
  • Ladan Fazli
  • Antonio Hurtado-Coll
  • Mark A. Rubin
  • Francesca Demichelis
  • Himisha Beltran
  • Martin Hirst
  • Marco Marra
  • Christopher A. Maher
  • Arul M. Chinnaiyan
  • Martin Gleave
  • Joseph R. Bertino
  • Martin Lubin
  • Yuzhuo Wang
  • Colin C. Collins
چکیده

Authors and Affiliations Colin C Collins, Stanislav V Volik, Anna V Lapuk, Yuwei Wang, Peter W Gout, Chunxiao Wu, Hui Xue, Hongwei Cheng, Anne Haegert, Robert H Bell, Sonal Brahmbhatt, Shawn Anderson, Ladan Fazli, Antonio Hurtado-Coll, Mark A. Rubin, Francesca Demichelis, Himisha Beltran, Martin Hirst, Marco Marra, Christopher A. Maher, Arul M. Chinnaiyan, Martin Gleave, Joseph R. Bertino, Martin Lubin & Yuzhuo Wang. Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia; BC Cancer Research Centre, BC Cancer Agency, Vancouver, BC, Canada; Weill Cornell Medical College, New York, NY, USA, Department of Pathology, University of Michigan, Ann Arbor, MI, USA, Cancer Institute of New Jersey, New Brunswick, NJ, USA, Dartmouth Medical School, Hanover NH, USA.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target.

Castrate-resistant prostate cancer (CRPC) and neuroendocrine carcinoma of the prostate are invariably fatal diseases for which only palliative therapies exist. As part of a prostate tumor sequencing program, a patient tumor was analyzed using Illumina genome sequencing and a matched renal capsule tumor xenograft was generated. Both tumor and xenograft had a homozygous 9p21 deletion spanning the...

متن کامل

The essential role of methylthioadenosine phosphorylase in prostate cancer

Prostatic epithelial cells secrete high levels of acetylated polyamines into the prostatic lumen. This distinctive characteristic places added strain on the connected pathways, which are forced to increase metabolite production to maintain pools. The methionine salvage pathway recycles the one-carbon unit lost to polyamine biosynthesis back to the methionine cycle, allowing for replenishment of...

متن کامل

Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.

The S-adenosylmethionine (AdoMet) salvage enzyme 5'-methylthioadenosine phosphorylase (MTAP) has been implicated as both a cancer target and a tumor suppressor. We tested these hypotheses in mouse xenografts of human lung cancers. AdoMet recycling from 5'-methylthioadenosine (MTA) was blocked by inhibition of MTAP with methylthio-DADMe-Immucillin-A (MTDIA), an orally available, nontoxic, picomo...

متن کامل

The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity.

Pemetrexed is a new-generation antifolate inhibitor of thymidylate synthase (TS) and a weaker inhibitor of glycinamide ribonucleotide transformylase (GARFT) required for de novo purine synthesis. Methylthioadenosine phosphorylase (MTAP) salvages purines by releasing adenine from methylthioadenosine and is often deleted in mesothelioma. The current study addresses the effect of MTAP on pemetrexe...

متن کامل

Therapeutic targeting of methylthioadenosine phosphorylase

Methylthioadenosine Phosphorylase is a well-known tumor suppressor and a regulator for purine and pyrimidine synthesis and metabolism. Several previous studies show MTAP could be a prognostic marker independent or coordinate with p16 in multiple cancer types. Furthermore, inhibitors of MTAP have been developed and tested in in vitro and in vivo experiment to support the selective tumor cell-kil...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012